My Lockbox

• Extremely easy in use.
• Hotkey to open Control Panel with a simple keystroke.
• Effective password protection.
• FAT, FAT32, NTFS volumes are supported.
• Supports all modern Windows operating systems (XP, Vista, 7) including 64-bit editions.
• Almost any folder on your computer can be password protected.
• Prevents you from locking system-critical folders, e.g. C:\Windows.
• Instant protection - no file scrambling or moving to another place.
• Trusted processes feature lets backup, antivirus or similar software to backup or scan your protected folder.
• Protects folders even in Windows safe mode.
• Skinned user interface.
• Freeware *

* Can be upgraded to My Lockbox Professional edition which enables you to protect any number of folders.

Source : spro.net